Propargylated aminoindans, processes for preparation, and uses thereof

US8609719B2 · kind B2 · utility

Assignees

• YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. · IL
• Technion Research & Development Foundation Limited · IL

Inventors

• Victor Piryatinsky · Netanya, IL
• Bronka Cohen · Netanya, IL
• David Lerner · Akron, US
• Dalia Pinkert · Kfar Sava, IL
• Istvan Miskolczi · Debrecen, HU
• Yaacov Herzig · Raanana, IL
• Hugo Gottlieb · Rehovot, IL
• Marta Weinstock-Rosin · Jerusalem, IL

Key dates

• Filing date: Oct 20, 2009
• Grant date: Dec 17, 2013
• Expiry date: Jul 26, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2602/08
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A method for treating an individual who has been identified as having Alzheimer's disease by administering orally to the individual a therapeutically effective amount of ladostigil or a pharmaceutically active salt thereof, wherein the therapeutically effective amount is 70 mg per day, 140 mg per day, or 200 mg per day. Also, a unit dosage form of ladostigil or a pharmaceutically active salt thereof in an amount of 50 mg, 70 mg, 80 mg or 100 mg.