Patent · US Active

Methylglyoxal-scavenging compounds and their use for the prevention and treatment of pain and/or hyperalgesia

US8609810B2 · kind B2 · utility

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18Claims

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Assignee

RUPRECHT - KARLS - UNIVERSITÄT HEIDELBERG · DE

Inventors

Peter Nawroth · Leimen, DE
Angelika Bierhaus · Heidelberg, DE
Thomas FLEMING · Heidelberg, DE

Key dates

Filing date	May 26, 2010
Grant date	Dec 17, 2013
Priority date	—
Expiry date	May 26, 2030

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61P43/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention relates to compounds which inhibit or antagonize the binding of methylglyoxal (MG) and/or other reactive carbonyl species (RCS) to an arginine- or lysine- containing protein, preferably an arginine- or lysine-containing cellular protein, such as a sodium ion channel, e.g. the sodium ion channel Na(v)1.8. Preferred scavenger compounds are peptides comprising several or multiple repeats of the amino acid sequence motif Gly-Glu-X-Pro (GEXP), wherein X is Arg or Lys, and pharmaceutical compositions thereof. The present invention furthermore relates to the use of the compounds as scavenger or antagonists of methylglyoxal and/or related reactive carbonyl species (RCS). The present invention furthermore relates to the use of the compounds for the prevention and/or treatment of pain, hyperalgesia and pain related diseases, in particular pain and/or hyperalgesia caused by or associated with methylglyoxal and/or reactive carbonyl species (RCS).

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.