Methods for preparing stable deoxygenated PEG-hemoglobin conjugate solutions comprising an antioxidant
US8609815B2 · kind B2 · utility
1Cited by
8References
22Claims
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Key dates
| Filing date | Sep 1, 2011 |
| Grant date | Dec 17, 2013 |
| Priority date | — |
| Expiry date | May 10, 2045 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/805
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention is a method for preparing stable HBOC solutions. Specifically, the method comprises the steps of deoxygenating a PEG-Hb conjugate and adding one or more antioxidants during or following the deoxygenating step to form a stabilized PEG-Hb conjugate. The Hb in the PEG-Hb conjugate is not crosslinked and the stabilized PEG-Hb conjugate has a p50 less than that of native SFH from the same animal source when measured under the same conditions. Specifically, the p50 is 6±2 mmHg or less than 10 mmHg.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.