Patent · US Active

Targeted nitroxide agents

US8609850B2 · kind B2 · utility

5Cited by

3References

9Claims

0Family size

Assignee

University of Pittsburgh—Of the Commonwealth System of Higher Education · US

Inventors

Peter Wipf · Pittsburgh, US
Marie-Celine Frantz · Pittsburgh, US

Key dates

Filing date	Sep 14, 2012
Grant date	Dec 17, 2013
Priority date	—
Expiry date	Sep 14, 2032

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D471/08
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Provided herein are compositions and related methods useful for free radical scavenging, with particular selectivity for mitochondria. The compounds comprise a nitroxide-containing group attached to a mitochondria-targeting group. The compounds can be cross-linked into dimers without loss of activity. Also provided herein are methods, for preventing, mitigating and treating damage caused by radiation. The method comprises delivering a compound, as described herein, to a patient in an amount and dosage regimen effective to prevent, mitigate or treat damage caused by radiation.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.