Silver and silver nanoparticle MALDI matrix utilizing online soft landing ion mobility
US8610058B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Nov 2, 2011 |
| Grant date | Dec 17, 2013 |
| Priority date | — |
| Expiry date | May 28, 2032 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2001/045
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Silver nanoparticles as a sample matrix for Matrix Assisted Laser Desorption Ionization (MALDI) along with a novel method for nanoparticle development is described herein. The silver nanoparticles were generated from silver ions on the surface of a MALDI plate utilizing a Soft Landing Ion Mobility (SLIM) instrument. Upon interaction with the surface the incident silver ions were labile and aggregated into the nanoparticle structures in a time dependent fashion. Post landing analysis were completed by Time of Flight mass spectrometry (TOF), and of particular interest in the spectra were the elimination of low mass interference peaks that generally plague organic based matrices. The approach of the present invention significantly decreases sample preparation time and may lead to a preparation free MALDI source by soft landing a matrix directly on the sample surface.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.