Microfluidic method for measurement or detection involving cells or biomolecules
US8614056B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Mar 23, 2011 |
| Grant date | Dec 24, 2013 |
| Priority date | — |
| Expiry date | Mar 23, 2031 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01L2300/0816
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Embodiments of the invention are related to microfluidic devices for detecting or determining the concentration of biomolecules in an analyte comprising: a channel, wherein a surface of said channel is fabricated to be functionalized with at least one molecule selected to interact with a biomolecule, said channel being configured to interact with a microsphere, wherein a surface of said microsphere is fabricated to be functionalized with at least one same or different molecule selected to interact with said biomolecule; a second channel in fluid communication with said first channel; a system to move fluid containing said microsphere through said first and second channels; and a system to measure a change in electrical impedance or optical microscopy across said second channel as said microsphere moves through said second channel. Other embodiments concern related devices, and methods of making and using.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.