Patent · US Active

GLP-1 analogues and their pharmaceutical salts and uses

US8614182B2 · kind B2 · utility

1Cited by

4References

51Claims

0Family size

Assignee

JIANGSU HANSOH PHARMACEUTICAL GROUP CO., LTD · CN

Inventors

Yali Wang · Lianyungang, CN
Aifeng Lü · 安丰镇, CN
Changan Sun · Shanghai, CN
Hengli Yuan · Shanghai, CN

Key dates

Filing date	Jan 31, 2012
Grant date	Dec 24, 2013
Priority date	—
Expiry date	Feb 11, 2032

Classification

Technology area (CPC G)Physics
CPC primaryG01N33/566
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

This invention discloses GLP-1 analogues and their pharmaceutical salts, wherein the GLP-1 analogue comprises an amino acid sequence of general formula (I), wherein Lys represents a modified lysine with a lipophilic acid. The GLP-1 analogues provided by this invention have the function of human GLP-1, and a longer half-life in vivo compared with the human GLP-1. Uses of such compounds and compositions include treating non-insulin-dependent diabetes, insulin-dependent diabetes, and obesity.X1-X2-Glu-Gly-Thr-Phe-Thr-Ser-Asp-X10-Ser-X12-X13-X14-Glu-X16-X17-Ala-X19-X20-X21-Phe-Ile-X24-Trp-Leu-X27-X28-X29-X30-X31-X32-X33-X34-X35-X36-X37-X38-X39-Lys Formula (I)—SEQ ID NO: 238

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.