Peptides, compositions and uses thereof
US8614187B2 · kind B2 · utility
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Key dates
| Filing date | Jun 22, 2012 |
| Grant date | Dec 24, 2013 |
| Priority date | — |
| Expiry date | Jun 22, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/47
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Described is an N-terminal hexapeptide fragment of maximakinin, QUB 698.8, which exhibits potent tissue selective actions on smooth muscle. It demonstrates a high degree of selectivity for arterial smooth muscle over small intestinal smooth muscle, causing potent relaxation of arterial smooth muscle, while causing less potent contraction of ileal smooth muscle. It may be used treatment of diseases of the cardiovascular system and in promotion of angiogenesis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.