Crystalline form VI of agomelatine, preparation method and application thereof

US8614251B2 · kind B2 · utility

Assignee

• LES LABORATOIRES SERVIER · FR

Inventors

• Hanbin Shan · County Road 325, CN
• Peng Zhang · Nanhu, CN
• Zhedong Yuan · Shanghai, CN
• Xudong Jiang · Shanghai, CN
• Yu Huang · Shanghai, CN
• Hubo Wang · Shanghai, CN
• Xufeng Cao · Xixia District, CN
• Xingdong Cheng · Lianyungang, CN
• Xiong Yu · Shanghai, CN

Key dates

• Filing date: Mar 9, 2010
• Grant date: Dec 24, 2013
• Expiry date: Aug 6, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C233/18
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides a new crystalline form of agomelatine, preparation and use thereof. The X-ray powder diffraction diagram of the agomelatine crystalline form shows main peaks at the diffraction angles 2θ 11.13°, 11.82°, 17.49°, 18.29°, 19.48°, 19.72°, 20.50°, 21.76°, 22.54°, 22.97°, 24.56°, 25.36°, 27.16° and 31.93°. Said new crystalline form is characterized by high purity, stability and good reproducibility, and thus is advantageous for the pharmaceutical formulation. In addition, the stability and solubility of said crystalline form are also superior over the several existing crystalline forms.