Cancer imaging and treatment

US8614290B2 · kind B2 · utility

Assignee

• TECHNISCHE UNIVERSITÄT MÜNCHEN · DE

Inventors

• Hans-Jürgen Wester · Ilmmünster, DE
• Horst Kessler · Schwalbach, DE
• Oliver Demmer · Birkenfeld, DE
• Ingrid Dijkgraaf · Neubiberg, DE

Key dates

• Filing date: Sep 1, 2008
• Grant date: Dec 24, 2013
• Expiry date: Dec 25, 2029

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A compound, or a pharmaceutically acceptable salt or ester thereof, comprises the structure: [(P1-S1j)p-L-(S2q-P2)r]t wherein: P1 and P2, which may be the same or different, are cyclic oligopeptide moieties, at least one of P1 and P2 having the motif B-Arg or B-(Me) Arg within the cyclic moiety, wherein B is a basic amino acid, a derivative thereof, or phenylalanine or a derivative thereof; S1 and S2 are spacer groups, which may be the same or different; L is a linker moiety containing at least two functional groups for attachment of the cyclic oligopeptides or spacer groups; n and q are independently 0 or 1; p and r are independently integers of 1 or more; and t is an integer of 1 or more, provided that, when t, p or r is greater than 1, the cyclic oligopeptide moiety, spacer group and/or the value of j or q may be the same or different between the multiple (P1-S1j) moieties or multiple (S2q-P2) moieties.