Patent · US Active

Nucleic acid molecules encoding A-beta binding polypeptides

US8614308B2 · kind B2 · utility

1Cited by

1References

3Claims

0Family size

Assignee

Boehringer Ingelheim International GmbH · DE

Inventors

John Park · Warthausen, DE
Cornelia Dorner-Ciossek · Ingelheim am Rhein, DE
Stefan Hoerer · Biberach an der Riß, DE
Lothar Kussmaul · Schemmerhofen, DE
Martin Lenter · Ulm, DE
Katharina Zimmermann · Biberach, DE
Gerald Beste · Evergem, BE
Toon Laeremans · Dworp, BE
Pascal MERCHIERS · Kasterlee, BE
Jo Vercammen · Sint-Pieters-Leeuw, BE

Key dates

Filing date	Sep 14, 2012
Grant date	Dec 24, 2013
Priority date	—
Expiry date	Sep 14, 2032

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2319/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The invention relates to biparatopic A-beta binding polypeptides and, more specifically, to biparatopic A-beta binding polypeptides comprising at least two immunoglobulin single variable domains binding to different epitopes of A-beta. The invention also relates to specific sequences of such polypeptides, methods of their production, and methods of using them, including methods of treatment of diseases such as Alzheimer's Disease.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.