Therapeutic agent delivery systems and devices

US8617143B2 · kind B2 · utility

Assignee

• The Regents of the University of California · US

Inventors

• Mark Bachman · Irvine, US
• Baruch Kuppermann · Laguna Beach, US
• Asheesh Divetia · Los Gatos, US
• Guann-Pyng Li · Irvine, US

Key dates

• Filing date: Dec 7, 2007
• Grant date: Dec 31, 2013
• Expiry date: Apr 12, 2031

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K9/025
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Devices, systems and methods for delivering pre-determined quantities of an active ingredient to a biological system are provided. In various embodiments, a device for controlled release of an active ingredient is provided, including a release aperture operably associated with a deflectable member, a base with a porous membrane substrate layer, and at least one chamber juxtaposed between the release aperture and the porous membrane layer. The chamber may contain a matrix including one or more active ingredients and an agent that expands when contacted with an aqueous solution. The device is suitable for implantation in a biological system and can be used for delayed and/or time release of specific drug dosages for various indications.