Injectable cross-linked hydrogels for biomaterial applications

US8617519B2 · kind B2 · utility

Assignee

• DePuy Synthes Products, Inc. · US

Inventors

• Valerie R. Binetti · Westtown, US
• Kristin B. Kita · West Chester, US
• Garland W. Fussell · Towanda, US
• Anthony M. Lowman · Wallingford, US
• Michele Marcolongo · Chester, US

Key dates

• Filing date: Jul 7, 2011
• Grant date: Dec 31, 2013
• Expiry date: Jan 8, 2032

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61L2430/38
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

An injectable hydrogel composition comprising: water; and poly(vinyl alcohol) chemically cross-linked with a second polymer to form a cross-linked resin, wherein the second polymer is selected from the group consisting of: a polyhydric alcohol compound, a polyvalent epoxy compound, a polyvalent amine compound, a dialdehyde compound, a diisocyanate compound, and mixtures thereof, wherein the cross-linked resin has a degree of cross-linking of from about 0.0001 mol/mL to about 0.002 mol/mL, and wherein the hydrogel is flowable when heated above its melting point.