Polymer conjugates of opioid antagonists
US8617530B2 · kind B2 · utility
8Cited by
29References
12Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 29, 2012 |
| Grant date | Dec 31, 2013 |
| Priority date | — |
| Expiry date | Nov 29, 2032 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P29/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides polymer conjugates of opioid antagonists comprising a polymer, such as poly(ethylene glycol), covalently attached to an opioid antagonist. The linkage between the polymer and the opioid antagonist is preferably hydrolytically stable. The invention also includes a method of treating one or more side effects associated with the use of opioid analgesics, such as constipation, nausea, or pruritus, by administering a polymer conjugate of the invention.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.