Multi-antigenic alphavirus replicon particles and methods
US8617533B2 · kind B2 · utility
11Cited by
59References
19Claims
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Key dates
| Filing date | May 6, 2008 |
| Grant date | Dec 31, 2013 |
| Priority date | — |
| Expiry date | Feb 2, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2770/36152
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Viral replicon selected nucleic acid expression libraries are useful for analyzing multiple antigens associated with a parasite, pathogen or neoplasia or for preparing immunogenic compositions for generating immune responses specific for the parasite, pathogen or neoplasia. Alphavirus replicon particles representative of the nucleic acid expression library are preferred. The nucleic acid library can be a random library, or it can be prepared after a selection step, for example, by differential hybridization prior to cloning into the replicon vector.
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