Nontypable Haemophilus influenzae antigens

US8617574B2 · kind B2 · utility

Assignee

• Valneva Austria GmbH · AT

Inventors

• Alexander Von Gabain · Wien, AT
• Eszter Nagy · Wien, AT
• Andreas Meinke · Pressbaum, AT
• Sanja Selak · Wien, AT
• Markus Hanner · Pressbaum, AT
• Margarita Smidt · Wien, AT
• Michaela Weissgram · Hinterbrühl, AT
• Birgit Noiges · Wien, AT
• Stefan Seidel · Wiener Neustadt, AT
• Julia Bacher · Wien, AT
• Christina Satke · Weitensfeld im Gurktal, AT
• Wolfgang Schueler · Wien, AT
• Martin Oleksiewicz · Wien, AT

Key dates

• Filing date: Feb 15, 2010
• Grant date: Dec 31, 2013
• Expiry date: Feb 15, 2030

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K2039/53
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to isolated nucleic acid molecules which encode an antigen from a nontypable Haemophilus influenzae (H. influenzae) species, a vector which comprises such nucleic acid molecule, and a host cell comprising such vector. Furthermore, the invention provides antigens from a nontypable Haemophilus influenzae species, as well as fragments and variants thereof, a process for producing such antigens, and a process for producing a cell, which expresses such antigen. More specifically such antigens are produced by or associated with bacterial infections caused by nontypable Haemophilus influenzae. Moreover, the present invention provides antibodies binding to such antigen, a hybridoma cell producing such antibodies, methods for producing such antibodies, a pharmaceutical composition comprising such nucleic acid molecule, antigen, vector or antibody, the use of such nucleic acid molecule, antigen, vector or antibody for the preparation of a pharmaceutical composition, methods for identifying an antagonist capable of binding such antigen or of reducing or inhibiting the interaction activity of such antigen, methods for diagnosing an infection with nontypable Haemop…