Patent · US Active

Ketoreductase polypeptides for the production of (S,E)-methyl 2-(3-(3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)-3-hydroxypropyl)benzoate

US8617853B2 · kind B2 · utility

12Cited by

20References

14Claims

0Family size

Assignee

Codexis, Inc. · US

Inventors

Jack Liang · San Mateo, US
Birthe Borup · Wesel, DE
Vesna Mitchell · San Jose, US
Emily Mundorff · Garden City, US
James Lalonde · Palo Alto, US
Gjalt W. Huisman · Redwood City, US

Key dates

Filing date	Dec 19, 2011
Grant date	Dec 31, 2013
Priority date	—
Expiry date	Aug 27, 2032

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12P17/12
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.