Chimeric toll-like receptor/MD-2 polypeptides and methods of use thereof
US8617880B2 · kind B2 · utility
1Cited by
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6Claims
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Inventor
Key dates
| Filing date | Jan 31, 2012 |
| Grant date | Dec 31, 2013 |
| Priority date | — |
| Expiry date | Jan 31, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention provides monoclonal antibodies that recognize the Toll-like Receptor 4/MD-2 receptor complex, and monoclonal antibodies that recognize the TLR4/MD2 complex as well as TLR4 when not complexed with MD-2. The invention further provides methods of using the monoclonal antibodies as therapeutics. This invention also provides soluble chimeric proteins, methods of expressing and purifying soluble chimeric proteins, and methods of using soluble chimeric proteins as therapeutics, in screening assays and in the production of antibodies.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.