Imidazo[1,2-a] pyridinyl bisphosphonates

US8618079B2 · kind B2 · utility

Assignee

• Isis Innovation Limited · GB

Inventors

• Frank Hallock Ebetino · Venice, US
• Adam W. Mazur · Cincinnati, US
• Mark Walden Lundy · Cincinnati, US
• Robert G. Russell · Granville, US

Key dates

• Filing date: Sep 22, 2009
• Grant date: Dec 31, 2013
• Expiry date: Oct 30, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/65068
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Novel imidazo[1,2-α]pyridinyl bisphosphonate compounds are disclosed, as well as methods of preparing the compounds, pharmaceutical compositions including the compounds, and administration of the compounds in methods of treating abnormal calcium and phosphate metabolism, including bone and joint diseases and other disorders.