Patent · US Active

Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds

US8618132B2 · kind B2 · utility

3Cited by

7References

8Claims

0Family size

Assignee

BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG · DE

Inventors

Dirk Stenkamp · Biberach, DE
Stephan Georg Mueller · Warthausen, DE
Gerald Juergen Roth · Biberach, DE
Thorsten Lehmann-Lintz · Ochsenhausen, DE
Klaus Rudolf · Warthausen, DE
Philipp Lustenberger · Warthausen, DE
Kristen Arndt · Ravensburg, DE
Ralf Lotz · Schemmerhofen, DE
Martin Lenter · Ulm, DE

Key dates

Filing date	May 15, 2008
Grant date	Dec 31, 2013
Priority date	—
Expiry date	Nov 16, 2029

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D495/04
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The present invention relates to alkyne compounds of general formula Iwherein the groups and residues A, B, W, X, Y, Z, R1 and R2 have the meanings given in claim 1. The invention further relates to pharmaceutical compositions containing at least one alkyne according to the invention. In view of their MCH-receptor antagonistic activity the pharmaceutical compositions according to the invention are suitable for the treatment of metabolic disorders and/or eating disorders, particularly obesity, bulimia, anorexia, hyperphagia and diabetes.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.