Indole amide derivatives and related compounds for use in the treatment of neurodegenerative diseases

US8618138B2 · kind B2 · utility

Assignees

• Katholieke Universiteit Leuven, KU LEUVEN R&D · BE
• ReMYND N.V. · BE

Inventors

• Gerard Griffioen · Linden, BE
• Tom Van Dooren · Koningshooikt, BE
• Veronica Rojas De La Parra · Haasrode, BE
• Arnaud Marchand · Leuven, BE
• Sara Allasia · Mechelen, BE
• Amuri Kilonda · Tienen, BE
• Patrick Chaltin · Zétrud-Lumay, BE

Key dates

• Filing date: Jun 11, 2010
• Grant date: Dec 31, 2013
• Expiry date: Jun 11, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention provides novel compounds and the novel compounds for use as a medicine, more in particular for the prevention or treatment of neurodegenerative disorders, more specifically certain neurological disorders, such as disorders collectively known as tauopathies, and disorders characterized by cytotoxic α-synuclein amyloidogenesis. The present invention also relates to the use of said novel compounds for the manufacture of medicaments useful for treating such neurodegenerative disorders. The present invention further relates to pharmaceutical compositions including said novel compounds and to methods for the preparation of said novel compounds.