Freeze-dried fibrin matrices and methods for preparation thereof
US8618258B2 · kind B2 · utility
4Cited by
31References
20Claims
0Family size
Assignee
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Key dates
| Filing date | May 7, 2012 |
| Grant date | Dec 31, 2013 |
| Priority date | — |
| Expiry date | May 7, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2533/56
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods for treating diseased or injured tissue by implanting into the tissue at a site of the disease or injury a porous freeze-dried fibrin matrix formed from plasma proteins. The proteins include fibrinogen cleaved by the action of thrombin at varying concentrations sufficient to cleave the fibrinogen and Factor XIII. The matrix has less than 10% residual moisture and is devoid of exogenous anti-fibrinolytic agents, plasminogen and of organic chelating agents. Alternatively, the plasma proteins comprise partially purified plasma proteins that are devoid of plasminogen.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.