Anti-CD147 antibodies, methods and uses
US8618264B2 · kind B2 · utility
4Cited by
3References
5Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 19, 2009 |
| Grant date | Dec 31, 2013 |
| Priority date | — |
| Expiry date | Dec 9, 2029 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/32
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides antibodies immunospecific for human CD147 capable of blocking bioactivity of CD147 associated with malignant disease such as the stimulation of MMPs from fibroblast cells by tumor cells, the release of VEGF, and the promotion of angiogenesis. The antibodies of the present invention of are useful in treating malignant disease and those diseases in which CD147 activity is plays a pathogenic role, such as diseases of the eye, lung, and cardiovascular system.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.