Hasylated polypeptides

US8618266B2 · kind B2 · utility

Assignee

• Fresenius Kabi Deutschland GmbH · DE

Inventors

• Harald Conradt · Braunschweig, DE
• Eckart Grabenhorst · Braunschweig, DE
• Manfred Nimtz · Bitterfeld-Wolfen, DE
• Norbert Zander · Marburg, DE
• Ronald Frank · Lehre, DE
• Wolfram Eichner · Rockenberg, DE

Key dates

• Filing date: Mar 11, 2005
• Grant date: Dec 31, 2013
• Expiry date: Aug 22, 2029

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to hydroxyalkylstarch (HAS)-polypeptide-conjugate (HAS-polypeptide) comprising one or more HAS molecules, wherein each HAS is conjugated to the polypeptide via a carbohydrate moiety or a thioether as well as to methods for the production thereof. In a preferred embodiment, the polypeptide is erythropoietin (EPO).