Patent · US Active

Process for preparing 4-[(1,6-dihydro-6-OXO-2-pyrimidinyl)amino]benzonitrile

US8618291B2 · kind B2 · utility

0Cited by

11References

17Claims

0Family size

Assignee

Tibotec Pharmaceuticals Ltd. · IE

Inventors

Didier Schils · Loupoigne, BE
Alfred Elisabeth Stappers · Oud-Turnhout, BE

Key dates

Filing date	Dec 14, 2011
Grant date	Dec 31, 2013
Priority date	—
Expiry date	Dec 14, 2031

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D239/47
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

This invention relates to a process for preparing 4-[(1,6-dihydro-6-oxo-2-pyrimidinyl)-amino]benzonitrile (I) starting from a 4-oxo-1,6-dihydro-pyrimidinylcarboxylic acid ester (II) or starting from a guanidine derivative which is reacted with an alkoxy-methylene malonic acid ester to an ester (II) which is converted to (I), which reaction sequence may be a one-pot procedure.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.