Methods and compositions of targeted drug development
US8618302B2 · kind B2 · utility
1Cited by
7References
26Claims
0Family size
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Key dates
| Filing date | Jan 6, 2011 |
| Grant date | Dec 31, 2013 |
| Priority date | — |
| Expiry date | Jan 6, 2031 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG16B15/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Provided herein are compounds having anti-proliferative effect. Also provided are compounds that can modulate the activity of multi-domain proteins comprising a dimerization arm and interdomain tether, such as EGFR, where an untethered, extended conformation is the active state and a tethered conformation is the inactive state, resulting in an autoinhibited configuration. Also provided are methods and pharmacophores for identifying such compounds. Other aspects provide methods or therapeutic treatment for proliferative diseases, disorders, or conditions, such as those associated with EGFR.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.