Sorafenib dimethyl sulphoxide solvate

US8618305B2 · kind B2 · utility

Assignee

• RANBAXY LABORATORIES LIMITED · IN

Inventors

• Jagdev Singh Jaryal · Kangra, IN
• Swargam Sathyanarayana · Delhi, IN
• Rajesh Kumar Thaper · Jammu, IN
• Mohan Prasad · Manesar, IN
• Sachin Deorao Zade · Yavatmal, IN
• Ajay Shankar Singh · Manesar, IN

Key dates

• Filing date: Jan 28, 2011
• Grant date: Dec 31, 2013
• Expiry date: Jan 28, 2031

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N30/02
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The present invention provides dimethyl sulphoxide solvate of 4-(4-{3-[4-chloro-3 -(trifluoromethyl)phenyl]ureido}phenoxy)-N2-methylpyridine-2-carboxamide, process for its preparation, pharmaceutical composition comprising it and its use for the treatment of cancer. The present invention also provides a novel HPLC method for the identification, quantification and isolation of related substances of sorafenib.