Luminescent dyes with a water-soluble intramolecular bridge and their biological conjugates

US8623324B2 · kind B2 · utility

Assignees

• AAT Bioquest, Inc. · US
• Becton, Dickinson and Company · US

Inventors

• Timothy Dubrovsky · Flemington, US
• Barnaby Abrams · Redwood City, US
• Zhenjun Diwu · Sunnyvale, US
• Qinglin Meng · Sunnyvale, US
• Jinfang Liao · Foster City, US
• Haitao Guo · Beijing, CN

Key dates

• Filing date: Jul 12, 2011
• Grant date: Jan 7, 2014
• Expiry date: Jan 25, 2032

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N33/533
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Chemically reactive dyes that are intramolecularly crosslinked with a water-soluble bridge, their bioconjugates and their uses are described. Reactive fluorescent dyes that have a water-soluble bridge are superior to those of conjugates of spectrally non-crosslinked dyes or the dyes that are crosslinked with a hydrophobic bridge. The invention includes reactive fluorescent dyes, their biological conjugates and uses.