Compositions and methods for treatment of angiogenesis in pathological lesions

US8623373B2 · kind B2 · utility

Assignee

• PHILOGEN S.P.A. · IT

Inventors

• Luciano Zardi · Genova, IT
• Dario Neri · Zürich, CH
• Barbara Carnemolla · Genova, IT
• Fredrik Nilsson · Stockholm, SE
• Lorenzo Tarli · Siena, IT
• Laura Borsi · Genova, IT
• Cornelia Halin · Zürich, CH

Key dates

• Filing date: Feb 22, 2001
• Grant date: Jan 7, 2014
• Expiry date: Jan 15, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Treatment of lesions of pathological angiogenesis, especially tumors, rheumatoid arthritis, diabetic retinopathy, age-related muscular degeneration. and angiomas. A conjugate is used comprising a molecule that exerts a biocidal or cytotoxic effect on target cells in the lesions and an antibody directed against an extracellular matrix component which is present in such lesions. The antibody may be directed against fibronectin-2 (IL-2), doxorubicin, interleukin-12(IL-12), Interferon-γ (IFN-γ), Tumor Necrosis Factor α(TNFα) or Tissue Factor protein (which may be truncated).