Methods and systems for predicting response of cells to a therapeutic agent
US8623592B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Aug 17, 2009 |
| Grant date | Jan 7, 2014 |
| Priority date | — |
| Expiry date | Feb 24, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/31
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides methods for treating patients which methods comprise methods for predicting responses of cells, such as tumor cells, to treatment with therapeutic agents. These methods involve measuring, in a sample of the cells, levels of one or more components of a cellular network and then computing a Network Activation State (NAS) or a Network Inhibition State (NIS) for the cells using a computational model of the cellular network. The response of the cells to treatment is then predicted124 based on the NAS or NIS value that has been computed. The invention also comprises predictive methods for cellular responsiveness in which computation of a NAS or NIS value for the cells (e.g., tumor cells) is combined with use of a statistical classification algorithm. Biomarkers for predicting responsiveness to treatment with a therapeutic agent that targets a component within the ErbB signaling pathway are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.