Chondroitin sulfate binding proteins and modulators thereof
US8623610B2 · kind B2 · utility
2Cited by
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16Claims
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Key dates
| Filing date | May 22, 2007 |
| Grant date | Jan 7, 2014 |
| Priority date | — |
| Expiry date | May 3, 2029 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2500/02
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Chondroitin sulfate polysaccharides with defined sulfation patterns can be synthesized. These chondroitin polysaccharides can be used to identify chondroitin sulfate binding proteins. Further, compounds that modulate the activity of chondroitin sulfate binding proteins can be identified. For example, TNF-α was found to bind specifically to CS-E and CS-E can be used to modulate the interaction of TNF-α with the TNF receptor.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.