15, 16-methylene-17-(1′-propenyl)-17,3′-oxidoestra-4-en-3-one derivative, use thereof, and medicament containing said derivative

US8623850B2 · kind B2 · utility

Assignee

• Bayer Intellectual Property GmbH · DE

Inventors

• Ulrich Klar · Berlin, DE
• Joachim Kuhnke · Leverkusen, DE
• Rolf Bohlmann · Berlin, DE
• Jan Hübner · Berlin, DE
• Sven Ring · Jena, DE
• Thomas Frenzel · Berlin, DE
• Frederik Menges · Schriesheim, DE
• Steffen Borden · Berlin, DE
• Hans-Peter Muhn · Berlin, DE
• Katja Prelle · Berlin, DE

Key dates

• Filing date: Dec 23, 2008
• Grant date: Jan 7, 2014
• Expiry date: Mar 8, 2030

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to 15,16-methylene-17-(1′-propenyl)-17-3′-oxidoestra-4-en-3-one derivatives with the general chemical formula I, where the Z, R4, R6a, R6b, R7 and R18 have the meanings stated in claim 1, and solvates, hydrates and salts thereof, including all crystal modifications and all stereoisomers of these compounds. The invention also relates to the use of these derivatives for the production of a drug for oral contraception and for the treatment of pre-, peri- and postmenopausal problems and drugs which contain such derivatives, in particular use in the aforesaid indications. The derivatives according to the invention have a progestational and in preferable cases also an antimineralcorticoid and neutral to slight androgenic activity.