Patent · US Active

Substituted N-heteroaryl tetrahydro-isoquinoline derivatives, preparation and therapeutic use thereof

US8623877B2 · kind B2 · utility

2Cited by
8References
16Claims
0Family size

Assignee

Inventors

Key dates

Filing dateNov 6, 2012
Grant dateJan 7, 2014
Priority date—
Expiry dateNov 6, 2032

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC07D413/14
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

The present disclosure relates to a series of substituted N-heteroaryl tetrahydro-isoquinoline derivatives of formula (I).wherein R, R1, R2, X, m, n and p are as described herein. More specifically, the compounds of this invention are modulators of H3 receptors and are, therefore, useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases modulated by H3 receptors including diseases associated with the central nervous system. Additionally, this disclosure also relates to methods of preparation of substituted N-heteroaryl tetrahydro-isoquinoline derivatives of formula (I) and intermediates therefor.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.