Fused pyrimidine-dione derivatives as TRPA1 modulators

US8623880B2 · kind B2 · utility

Assignee

• Glenmark Pharmaceuticals S.A. · CH

Inventors

• Sachin Sundarlal Chaudhari · Jamkhed, IN
• Sukeerthi Kumar · Navi Mumbai, IN
• Abraham Thomas · Jamkhed, IN
• Nisha Parag Patil · Mumbai, IN
• Ashok Bhausaheb Kadam · Navi Mumbai, IN
• Vishal Deshmukh · San Diego, US
• Sachin Vasantrao Dhone · Ter, IN
• Rajendra Prakash Chikhale · Ahmednagar, IN
• Neelima Khairatkar-Joshi · Thane, IN
• Indranil Mukhopadhyay · Navi Mumbai, IN

Key dates

• Filing date: Mar 17, 2010
• Grant date: Jan 7, 2014
• Expiry date: May 7, 2030

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P29/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention described herein relates to novel fused pyrimidinediones derivatives of formula (I) which are TRPA (Transient Receptor Potential subfamily A) modulators. In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by TRPA1 (Transient Receptor Potential subfamily A, member 1). This invention also provides processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPA1.