Bis-benzimidazole derivatives as hepatitis C virus inhibitors

US8623899B2 · kind B2 · utility

Assignee

• Janssen Research & Development Ireland · IE

Inventors

• David Craig McGowan · Vilvoorde, BE
• Samuël Dominique Demin · Ekeren, BE
• Stefaan Julien Last · Lint, BE
• Koen Vandyck · Beringen, BE
• Pierre Jean-Marie Bernard Raboisson · Sligo, IE

Key dates

• Filing date: Aug 6, 2010
• Grant date: Jan 7, 2014
• Expiry date: Aug 6, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Inhibitors of HCV replication of formula Iincluding stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein R and R′ have the meaning as defined herein.The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HCV inhibitors, in HCV therapy.