Alteration of Fc-fusion protein serum half-lives by mutagenesis
US8624007B2 · kind B2 · utility
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7Claims
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Key dates
| Filing date | Mar 31, 2010 |
| Grant date | Jan 7, 2014 |
| Priority date | — |
| Expiry date | May 4, 2031 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/30
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention provides for a modified Fc-fusion protein in which at least one amino acid from the heavy chain constant region selected from the group consisting of amino acid residues 250, 314, and 428 is substituted with another amino acid which is different from that present in the unmodified Fc-fusion protein, thereby altering the binding affinity for FcRn and/or the serum half-life in comparison to the unmodified Fc-fusion protein.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.