Cancer imaging and treatment

US8628750B2 · kind B2 · utility

Assignee

• TECHNISCHE UNIVERSITÄT MÜNCHEN · DE

Inventors

• Hans-Jürgen Wester · Ilmmünster, DE
• Norman Koglin · Berlin, DE
• Markus Schwaiger · Munich, DE
• Horst Kessler · Schwalbach, DE
• Burkhardt Laufer · Birkenfeld, DE
• Oliver Demmer · Birkenfeld, DE
• Martina Anton · Vaterstetten, DE

Key dates

• Filing date: Feb 27, 2007
• Grant date: Jan 14, 2014
• Expiry date: Jun 21, 2029

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided herein are compounds or conjugates useful for diagnostic imaging and/or therapeutic purposes. Each compound or conjugate comprises a ligand for the chemokine receptor CXCR4 and a detectable label. The ligand has a binding affinity for the CXCR4 receptor, measured as IC50 in the presence of 125I-CPCR4, of 250 nM or lower, and the ligand comprises a cyclic oligopeptide moiety having the motif B-Arg or B-(Me)Arg within the cyclic moiety, wherein B is a basic amino acid, a derivative thereof, or phenylalanine, provided that the motif is B-Arg when B is a Nα-methyl derivative of a basic amino acid.