System and method for quantifying fragile X mental retardation 1 protein in tissue and blood samples
US8628934B2 · kind B2 · utility
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Key dates
| Filing date | Jun 11, 2012 |
| Grant date | Jan 14, 2014 |
| Priority date | — |
| Expiry date | Jun 11, 2032 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/30
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A system and method for the detection and quantification of fragile X mental retardation protein (FMRP) in human tissue and blood samples. The system includes several high avidity monoclonal antibodies that may be provided on Xmap microspheres to capture FMRP from a tissue or blood specimen. The resulting complex is reacted with a polyclonal anti-FMRP rabbit antibody and then mixed with an anti-rabbit IgG antibody conjugated to phycoerythrin. Fluorescence emitted from the resulting complex is a function of the amount of FMRP present in the specimen.
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