Patent · US Active

Method for inducing a TRIF-bias

US8629116B2 · kind B2 · utility

0Cited by

2References

1Claims

0Family size

Assignee

GLAXOSMITHKLINE BIOLOGICALS SA · BE

Inventors

William S. Bowen · Hamilton, US
Jay Evans · Hamilton, US
Melinda M. Hutton · Hamilton, US
David A. Johnson · Boise, US
Laurie A. Minns · Shoreline, US

Key dates

Filing date	Dec 23, 2009
Grant date	Jan 14, 2014
Priority date	—
Expiry date	Jan 4, 2030

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61K2039/55572
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The use of a selected aminoalkyl glusoaminide 4-phosphate (AGP) CRX-547 to induce a TRIF biased response in a human system, which results in reduced levels of MyD88-dependent cytokines relative to the MyD88-dependent cytokines induced by its diastereomer AGP CRX-527.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.