Dual targeting of MIR-208 and MIR-499 in the treatment of cardiac disorders
US8629119B2 · kind B2 · utility
5Cited by
1References
26Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 4, 2010 |
| Grant date | Jan 14, 2014 |
| Priority date | — |
| Expiry date | Mar 7, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2330/51
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides a method of treating or preventing cardiac disorders in a subject in need thereof by inhibiting the expression or function of both miR-499 and miR-208 in the heart cells of the subject. In particular, specific protocols for administering inhibitors of the two miRNAs that achieve efficient, long-term suppression are disclosed. In addition, the invention provides a method for treating or preventing musculoskeletal disorders in a subject in need thereof by increasing the expression or activity of both miR-208 and miR-499 in skeletal muscle cells of the subject.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.