Dispiropyrrolidine derivatives
US8629133B2 · kind B2 · utility
20Cited by
0References
31Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 9, 2012 |
| Grant date | Jan 14, 2014 |
| Priority date | — |
| Expiry date | May 9, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D487/10
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A compound that inhibits interaction between murine double minute 2 (Mdm2) protein and p53 protein and exhibits anti-tumor activity is provided. The present invention provides a dispiropyrrolidine derivative represented by the following formula (1), which has various substituents, inhibits interaction between Mdm2 protein and p53 protein and exhibits anti-tumor activity, wherein R1, R2, R3, ring A, and ring B in formula (1) respectively have the same meanings as defined in the specification.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.