Alpha helical mimics, their uses and methods for their production

US8629241B2 · kind B2 · utility

Assignee

• The University Of Queensland · AU

Inventors

• David Fairlie · Faulconbridge, AU
• Nicholas E. Shepherd · Cardiff, GB

Key dates

• Filing date: May 30, 2012
• Grant date: Jan 14, 2014
• Expiry date: May 30, 2032

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are short chain peptides that are constrained to adopt an alpha helicial conformation and their use as alpha helical scaffolds for directing amino acid side chains into positions analogous to those found in longer chain alpha helical peptides. Also disclosed is the use of these peptides for attaching peptidic or non-peptidic appendages in order to mimic side chains of longer alpha helical peptides. The peptides find use in mimicking naturally occurring peptides or proteins or in preparing new materials.