Tricyclic pyrimidine derivatives as wnt antagonists

US8629272B2 · kind B2 · utility

Assignee

• Deutsches Krebsforschungszentrum · DE

Inventors

• Florian Fuchs · Weil am Rhein, DE
• Daniel Gilbert · Koblenzer Straße, DE
• Corinna Koch · Lorsch, DE
• Rajendra-Prasad Maskey · Heidelberg, DE
• Sandra Steinbrink · Eppstein, DE
• Michael Boutros · Heidelberg, DE

Key dates

• Filing date: Jun 25, 2010
• Grant date: Jan 14, 2014
• Expiry date: Jun 25, 2030

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to compounds having the general formula (I) with the definitions of X1-X3, Y1, Y2, L1, R1 and R2 given below and/or solvates, hydrates, esters and pharmaceutically acceptable salts thereof. Furthermore, the invention relates to the use of said compounds for modulating of the Wnt signalling pathway activity and their use as a medicament, preferably for the treatment of cancer.