Non-human transgenic mammal for the constant region of the class a human immunoglobulin heavy chain and applications thereof
US8629317B2 · kind B2 · utility
25Cited by
3References
22Claims
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Key dates
| Filing date | Oct 21, 2004 |
| Grant date | Jan 14, 2014 |
| Priority date | — |
| Expiry date | Sep 5, 2028 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2800/30
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention relates to a non-human transgenic mammal with an IgH locus modified by replacement of the switching sequence Sμ with all or part of a transgene comprising the gene Cα of a class A human immunoglobulin, including at least the exon, coding for the CH3 domain and the membrane exon and the applications of the above for the production of humanized class IgA antibodies.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.