Transgenic animals for analyzing CYP3A4 cytochrome P450 gene regulation
US8629318B2 · kind B2 · utility
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6References
15Claims
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Key dates
| Filing date | Aug 12, 2010 |
| Grant date | Jan 14, 2014 |
| Priority date | — |
| Expiry date | Dec 14, 2031 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA01K2267/0393
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to the generation of non-human transgenic animals comprising a reporter construct for producing a detectable amount of a reporter molecule operably linked to a transcriptional regulatory nucleic acid molecule from the human CYP3A4 gene located between the initiation of transcription site of the gene and a position located 13,000 nucleotides upstream from the site. The invention also relates to the use of these animals for determining the effect of a compound, particularly, but not exclusively, a xenobiotic or steroid, on the regulation of expression of the CYP3A4 gene in a human.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.