Directed evolution and in vivo panning of virus vectors
US8632764B2 · kind B2 · utility
38Cited by
1References
25Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 29, 2009 |
| Grant date | Jan 21, 2014 |
| Priority date | — |
| Expiry date | Jan 14, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2750/14151
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides methods of achieving directed evolution of viruses by in vivo screening or “panning” to identify viruses comprising scrambled AAV capsids having characteristics of interest, e.g., tropism profile and/or neutralization profile (e.g., ability to evade neutralizing antibodies). The invention also provides scrambled AAV capsids and virus particles comprising the same.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.