High molecular weight derivatives of vitamin K-dependent polypeptides

US8632771B2 · kind B2 · utility

Assignees

• Regents of the University of Minnesota · US
• The United States of America as represented by Department of Veterens Affairs · US

Inventors

• Gary L. Nelsestuen · Windom, US
• Ronald Bach · Kingsley, US
• Matthew T. Stone · Cambridge, US
• Stephen Harvey · Santa Monica, US

Key dates

• Filing date: Apr 4, 2007
• Grant date: Jan 21, 2014
• Expiry date: Jun 20, 2030

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Modifications of vitamin K-dependent polypeptides that lead to enhanced protein function on a weight or molar basis and/or increase of protein lifetime in the circulation are described. Both objectives are important for using vitamin K-dependent polypeptides for pro- and anti-coagulation therapies, as well as for other uses in the circulation.