Patent · US Active

System and method for delivery of DNA-binding chemotherapy drugs using nanoparticles

US8632789B2 · kind B2 · utility

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Key dates

Filing dateNov 1, 2011
Grant dateJan 21, 2014
Priority date—
Expiry dateNov 17, 2031

Classification

  • Technology area (CPC Y)Emerging Cross-Sectional Technologies
  • CPC primaryY10T428/2982
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

System and method for loading the front line anticancer drug, doxorubicin (DOX) onto DNA-capped gold nanoparticles whose duplex DNA has been designed for specific DOX intercalation. Since each AuNP contains about 108 high affinity drug sites, this design allows for a high local DOX concentration on the particle. Drug binding was confirmed by monitoring the increase in DNA melting temperature, the shift in the plasmon resonance maximum, and the increase in the NP hydrodynamic radius as a function of [DOX]/[DNA] ratio. The feasibility of the nanoparticles as a drug delivery system was demonstrated by showing that particle-bound DOX could be transferred to a target DNA.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.