System for delivery of protein in insoluble fibrillar or aggregate form
US8632803B2 · kind B2 · utility
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33Claims
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Key dates
| Filing date | Feb 18, 2009 |
| Grant date | Jan 21, 2014 |
| Priority date | — |
| Expiry date | Dec 24, 2029 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P3/10
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A pharmaceutical composition containing a therapeutic protein which is particularly amenable to oral administration by providing stability in the gastrointestinal tract. Insoluble fibrils or aggregates of the therapeutic protein in the pharmaceutical composition are encapsulated in a lipidated glycosaminoglycan particle, coated with a multi-layer of lipids and lipid-glycosaminoglycan conjugates, or present as unencapsulated and uncoated insoluble fibrils or aggregates.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.