Patent · US Active

Microcrystalline cellulose and calcium phosphate compositions useful as pharmaceutical excipients

US8632818B2 · kind B2 · utility

2Cited by

6References

15Claims

0Family size

Assignee

FMC Corporation · US

Inventors

Gregory Thoorens · Brussels, BE
Bruno LeClercq · Brussels, BE
Thomas Ruszkay · Readington, US

Key dates

Filing date	Nov 2, 2010
Grant date	Jan 21, 2014
Priority date	—
Expiry date	Dec 21, 2030

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61K47/38
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Compositions containing calcium phosphate and microcrystalline cellulose are useful as excipients in the preparation of solid dosage forms containing active pharmaceutical ingredients, particularly those prepared by processes involving multiple compaction steps. The recompactibility performance of such compositions is improved through the use of calcium phosphate having a relatively small particle size, e.g., a median particle size of not more than about 20 microns or not more than about 10 microns.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.